Clinical Usefulness and Predictability of Seoul National University Prostate Cancer Risk Calculator (SNU-PCRC)

Article information

J Urol Oncol. 2020;18(3):215-221
Publication date (electronic) : 2020 December 30
doi :
1Department of Urology, Seoul National University Hospital, Seoul, Korea
2Department of Urology and Andrology, JSK Medical University Astana, Astana, Kazakhstan
ㆍ This study was supported by the National R&D Program for Cancer Control, Ministry of Health and Welfare, Republic of Korea (grant numbers: HA17C0039).
Corresponding Author: Chang Wook Jeong Department of Urology, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul 03080, Korea E-mail: Tel: +82-2-2072-3899, Fax: +82-2-742-4665
Received 2020 September 24; Revised 2020 November 12; Accepted 2020 November 16.



To evaluate the clinical usefulness of the Seoul National University Prostate Cancer Risk Calculator (SNU-PCRC) to reduce unnecessary prostate biopsy and to increase the detection rate of high-risk cancer.

Materials and Methods

We retrospectively analyzed 546 patients who underwent prostate biopsy between 2014 and 2016. The subjects were divided into 2 groups based on the type of risk calculator used: conventional and SNU-PCRC group. In the SNU-PCRC group, prostate biopsy was recommended when the probability of SNU-PCRC was more than 30%.


The SNU-PCRC group had significantly smaller prostate volume (p=0.010) and significantly more digital rectal examination and transrectal ultrasonography (TRUS) abnormalities (p=0.011 and p=0.010, respectively). Overall detection (71.9% vs. 32.1%) and high-risk cancer detection rates (40.6% vs. 19.3%) were significantly higher in the gray zone (prostate-specific antigen=4–10 ng/mL) (p<0.001 and p–0.006). The group with prostate cancer risk ≥30% on the SNU-PCRC compared to <30% group, overall detection rate of 72.3% versus 30.2% and high-risk detection rate of 60.6% versus 18.3% were significantly different (p<0.001 and p<0.001). Applying the SNU-PCRC to the conventional group could avoid unnecessary prostate biopsy in 50.6%.


SNU-PCRC is clinically useful to reduce unnecessary prostate biopsy and increase overall detection rate and high-risk cancer detection rate.


Prostate cancer (PCa) is the second most common cancer in men worldwide. It is the sixth cause of cancer related deaths.1 PCa is common, and one of the major reasons is that the start of the use of a screening tool called pros-tate-specific antigen (PSA).2 However, PCa screening based on these PSA values lacks specificity.3 The lack of specific-ity leads to overdiagnosis and excessive prostate biopsy.4 Prostate biopsy may be accompanied by morbidity and mor-tality as well as socioeconomic costs and discomfort.5 Due to the associated mortality and morbidity, it is difficult and crucial to determine if biopsy is indicated in practice.6 To assist in this decision, several studies have examined vari-ous nomograms and calculators.711 In this regard, we developed and announced the “Seoul National University Prostate Cancer Risk Calculator (SNU-PCRC)” mobile ap-plication in 2014. In our previous study, we compared SNU-PCRC with the European Randomized Study of Screening for Prostrate Cancer Risk Calculator (ERSPC- RC) and the Prostate Cancer Prevention Trial Risk Calcula-tor (PCPT-RC) calculators. Our calculator has been designed to fit the characteristics of Korean populations and has high-er prediction accuracy than other calculators.12

We analyzed the actual clinical use of the SNU-PCRC for approximately 2.5 years from 2014 and explore its use-fulness in this study.

Materials and Methods

1. Seoul National University Prostate Cancer Risk Calculator

The SNU-PCRC was developed on the basis of data from 5,278 people who underwent prostate biopsy of more than 12-core between 2003 and 2010 in Seoul National University Bundang Hospital. PSA level, patients age, pros-tate size, abnormality on digital rectal examination or trans-rectal ultrasonography (TRUS) are the variables that constitute the calculator.12 The nomogram predicting the proba-bility of PCa was developed using this final multivariate lo-gistic regression model. The multivariate model was constructed based on a significant variable with a p-value of 0.05 or less in the univariate analysis. In the model, PSA levels and prostate size were standardized by log transfor-mations. The logit of SNU-PCRC was calculated as (0.21)+ (0.071×Age)+(2.379×log10PSA)-(4.775×log10Vol)+(0.544× TRUS)+(0.397×DRE). Head-to-head comparison was per-formed with the European Randomized Study of Screening for Prostate Cancer Risk Calculator (ERSPC-RC) and the PCPT-RC for the same cohort. The prediction accuracy of SNU-PCRC (area under the curve [AUC], 0.811; 95% confidence interval [CI], 0.786–0.833) was better than that of ERSPC-RC (AUC, 0.768; 95% CI, 0.742–0.792; p<0.001) and PCPT-RC (AUC, 0.704; 95% CI, 0.676–0.731; p<0.001).

The threshold probability of SNU-PCRC was chosen as the percentage of the highest sensitivity and specificity in the receiver operating characteristic (ROC) curve and com-pared with the traditional PSA cutoff >4 ng/mL. In the pre-vious study, the threshold probability of SNU-PCRC was 30%, sensitivity was 76.3%, specificity was 61.3%, false positive rate was 56.3% and false negative rate was 85.7%. The sensitivity, specificity, positive predictive value, and negative predictive value of PSA 4 ng/mL were 86.8%, 26.9%, 41.6%, and 77.3% respectively.

2. Study Sample

The study was approved by the Institutional Review Board of Seoul National University Hospital (IRB No: 1710-077-893). Content and protocol associated with this study followed the Declaration of Helsinki guidelines. We retrospectively analyzed prospectively collected data of patients that visited Seoul National University Hospital from January 2014 through August 2016. All patients underwent transrectal ultrasound prostate 12-core systematic biopsy and patients with PSA >100 ng/mL were excluded. Patients under active surveillance with PCa diagnosis were excluded. Finally, 546 patients were included.

3. Study Design

We divided patients into 2 groups: a group that under-went PCa risk assessment with the SNU-PCRC calculator and a group that did not (conventional group). The conventional group was a group that performed biopsy based on PSA levels alone. Prostate biopsy was routinely conducted on 12 cores with conventional guided TRUS biopsy and conducted by trained professional doctors. Approximately 50% of the biopsies were conducted by urologists and 50% by radiologists. For accuracy of diagnosis, tissue obtained by TRUS biopsy was reviewed by 2 experienced genito-urinary pathologists. In SNU-PCRC group, prostate biopsy was recommended when probability of PCa according to the SNU-PCRC was more than 30%. In the non-SNU-PCRC group, PSA screening was used as a reference for prostate biopsy. Pre-operational demographics and post biopsy out-comes include various data such as PSA, DRE findings, TRUS abnormal findings, volume and prostate biopsy core number, number of positive cores, Gleason score, overall detection rate, and high-risk detection rate. High-risk PCa was defined as a cancer with a Gleason score of 7 or higher. Abnormal findings on TRUS biopsy include hypoechoic lesions and hyperechoic lesions, as well as abnormal flow lesions in color Doppler images.

4. Statistical Analysis

Statistical analysis for continuous variables, mean, and standard deviation are shown. Variables of categories are indicated by frequencies of events (%). Primary endpoint of the study was overall detection rate. Secondary endpoint was high-risk PCa detection rate. Outcomes were analyzed using analysis of variance, t-paired test, and crossover analysis. Specificity, sensitivity, positive predictive value, and negative predictive value were analyzed using ROC curve.


1. Clinical Characteristics of Previous Prostate Biopsy of Patients

Table 1 reveals clinical characteristics of 546 patients. There was no significant difference in PSA averages between the conventional and the SNU-PCRC group. However, the SNU-PCRC group had more suspicious DRE findings and abnormal TRUS findings than the conventional group (p=0.011 and p=0.002). Prostate volume was relatively small in the SNU-PCRC group (p=0.010).

Patient characteristics before prostate biopsy

2. Comparison of Prostate Biopsy Outcomes Between the SNU-PCRC Group and the Conventional Group

Table 2 reveals the comparison of outcomes after prostate biopsy between the 2 groups. Although not significant, the prostate volume was larger in the conventional group. Overall detection and high-risk PCa detection were sig-nificantly higher in the SNU-PCRC group (p=0.001 and p=0.036). We subdivided overall detection and high-risk de-tection PCa into 3 groups according to PSA: PSA <4 ng/mL, PSA 4–10 ng/mL, and PSA >10 ng/mL. Among them, the SNU-PCRC group revealed higher overall and high-risk detection rate especially in 4–10 sections called gray zone.

Results of prostate biopsy according to SNU-PCRC application

Fig. 1 reveals the trend of detection rates overall, in the SNU-PCRC, and conventional populations at the 3 sections below PSA 4, PSA 4–10, and above PSA 10. Most of them have a higher detection rate towards PSA>10 ng/mL. However, based on SNU-PCRC, overall detection in the gray zone (PSA 4–10 ng/mL) is higher than in the PSA>10 ng/mL group.

Fig. 1.

Overall prostate cancer detection rate and high- risk prostate cancer detection rate according to prostate-specific antigen (PSA) interval. SNU-PCRC: Seoul National University Prostate Cancer Risk Calculator.

In 18 patients (6.6%) who underwent TRUS biopsy scoring with PSA<4 ng/mL in the SNU-PCRC group, the mean age was 67.2±7.0 years, PSA was 2.4±1.3 ng/mL, and the prostate volume was 26.0±9.7 mL. The overall rate of de-tection and the proportion of high-risk cancer was 44.4%. Patients who underwent biopsy with PSA≤4 ng/mL were patients with DRE and TRUS abnormalities, or other dis-eases, and were suspected of PCa based on radiology findings and follow-up examination.

3. SNU-PCRC Application in Conventional Group Patients

SNU-PCRC was applied to the patients in the conventional group. The conventional group was then divided into 2 groups: those with a SNU-PCRC probability score of >30% and those with a probability score of <30%. In patients with a probability score >30%, the overall detection rate and the high-risk cancer detection rate were 72.8% and 61.8%, respectively. On the other hand in patients with a probability score of <30%, the overall detection rate and the high-risk cancer detection rate were 26% and 15.5%, respectively.


When considering prostate biopsy through PSA screening tests, there are many ambiguities about whether to conduct a biopsy or not. PSA-based screening contributed sig-nificantly to PCa-specific mortality reduction.13,14 However, PSA-based screening leads to unnecessary invasive tests and overdiagnosis.15 It can cause complications due to biopsy such as infections. The is also the risk of infection with multidrug resistant bacteria.16,17 Feliciano et al.16 reported that the incidence of resistant bacteria increased in patients that developed infection after prostate biopsy. Otrock et al.18 reported that fluoroquinolone resistant Escherichia coli was detected in 50% of patients admitted for urinary tract infection (UTI) after prostate biopsy. Additionally, several studies have reported cases of sepsis and disseminated intra-vascular coagulation deaths due to antibiotic resistant bac-teria after prostate biopsy.1921 Although prophylactic anti-biotics were used, prostate biopsy could cause complications such as UTI. Additionally, antibiotic resistant bacteria may be acquired and leading to sepsis and death. After prostate biopsy, infection complications will may result in an increase in treatment costs for the patient even if the patient becomes asymptomatic and healthy. Unnecessary biop-sy causes inspection costs and this can be a great burden on patients. For these reasons, the decision to perform a prostate biopsy must be taken with caution. SNU-PCRC fa-cilitates more effective decision-making for invasive procedures in such situations. The SNU-PCRC calculates cancer risk using age, PSA, suspicious findings in digital rectal ex-amination, prostate volume, and abnormal findings in TRUS.22 In our study, the SNU-PCRC group revealed a 1.5 times higher overall detection rate or high-risk PCa de-tection rate than the conventional group (Table 2). Additionally, we observed a difference of detection rate of more than 2 times in the gray zone when PSA 4–10 ng/mL, the value that we are concerned about whether biopsy is conducted (Fig. 1). The use of SNU-PCRC allows improved patient selection and increased detection rate. The selection of these patients and increase in cancer detection rates have an advantage of reducing the cost of an annual PCa screening. Compared to PSA alone, it does not add much cost, but can increase efficiency.

The overall detection rate and the proportion of high-risk PCa was 44.4% when the SNU-PCRC was used for cases scoring PSA<4 ng/mL. Patients with a high-risk of PCa with PSA<4 ng/mL were characterized by a small volume and abnormal ultrasonographic findings. The mean prostate volume was 26.0±9.7 mL. We found that 77% of the cases showed abnormal findings in TRUS, and 22.2% had sus-pected DRE findings. Prostate volume is an important com-ponent of SNU-PCRC. Although PSA tends to increase with the prostate volume, the detection rate of cancer in prostate biopsy tends to increase with decreased prostate volume because the smaller the tumor, the higher the proba-bility of a biopsy core contacting the tumor.23 In other pre-dictive nomograms, prostate volume was an important pa-rameter and showed a tendency to decrease with increasing prostate volume.24 PSA density (PSAD), which is the ratio between the absolute PSA value and the prostate volume, is used to classify PSA based on prostate volume measured by ultrasound. The lower the prostate volume, the higher the PSAD value. The PSAD of benign prostatic hyperplasia is low and the PSAD of PCa is high.25

As can be seen in Table 3, prostate biopsy might be avoided in approximately 74% of patients when SNU- PCRC was applied to the conventional group. When SNU- PCRC was applied to the conventional group, 68.5% patients had <30% probability of PCa considering prostate bi-opsy in SNU-PCRC. Of these, 26% had cancer. Conversely, 74% of patients were cancer-free. If SNU-PCRC was ap-plied, 219 patients, 50.6% of the total conventional group patients, could have avoided an unnecessary biopsy. Considering only high-risk PCa, unnecessary biopsies were reduced in 57.8% of the total conventional group. By using SNU-PCRC, we can avoid unnecessary use of prostate biop-sy that can cause complications. Reducing unnecessary bi-opsy reduces patient care costs. Ninety-four patients were observed during the same period after SNU-PCRC was ap-plied, accounting for 40% of SNU-PCRC patients. The mean age of these patients was 68.4±8.3 years, PSA was 4.47±1.70 ng/mL, mean prostate volume was 55.36±25.79 mL, 7.44% of patients had abnormal TRUS findings, and 2.12% of patients had DRE abnormalities.

Result of applying SNU-PCRC to convention group

SNU-PCRC is useful and excellent, but there are a few shortcomings. Since the sensitivity and specificity of SNU-PCRC are not 100%, a positive diagnosis may be missed with a biopsy even if the patient may have PCa. Recently, dynamic contrast-enhanced, diffusion-weighted imaging, T2-weighted combined multiparametric magnetic resonance imaging (MRI), and magnetic resonance fusion biopsy have recently been beneficial in diagnosing PCa.25,26 Techniques for detecting PCa using MRI have been im-proved by application of apparent diffusion coefficient value and Prostate Imaging Reporting and Data System (PIRADS) scoring system.27 It is applied to various AS protocols.28 We think that this MRI-related scoring system could improve the sensitivity and specificity by applying PIRADS scoring system as an element to SNU-PCRC. Our study has several limitations. First, this study is a retro-spective study and cannot be free from selection bias. Second, the SNU-PCRC group may have been selected as a group with a slightly higher PCa risk compared to the control group due to the application of the PCa risk calculator. There may be a bias in the underlying nature of the patient population.


When SNU-PCRC is applied, the PCa detection rate is higher than when PSA, DRE, TRUS abnormality, and age, especially in the gray zone between PSA 4–10 ng/mL are considered as predictors of risk. It can effectively assist in the determination of invasive procedures in patients with PSA 4–10 ng/mL. It can facilitate in reducing unnecessary biopsy and reducing socioeconomic costs.



The authors claim no conflicts of interest.


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Article information Continued

Table 1.

Patient characteristics before prostate biopsy

Variable Conventional group (n=432) SNU-PCRC group (n=114) p-value
Age (yr) 67.1±8.1 68.7±8.8 0.176
BMI (kg/m2) 24.22±3.20 24.41±3.12 0.668
PSA (ng/mL) 10.1±12.32 12.0±15.7 0.395
DRE suspicious finding 86 (19.9) 32 (26.3) 0.011
Previous TRUS abnormal findings 179 (41.4) 72 (63.2) 0.002
Previous TRUS volume (mL) 55.6±26.9 47.4±21.4 0.010
Total biopsy core number     0.119
 12 343 (79.4) 80 (70.2)  
 13 71 (16.4) 34 (29.8)  
 14 18 (4.2) 0 (0)  

Values are presented as mean±standard deviation or number (%).

SNU-PCRC: Seoul National University Prostate Cancer Risk Calculator, BMI: body mass index, PSA: prostate specific antigen, DRE: digital rectal examination, TRUS: transrectal ultrasonography.

Table 2.

Results of prostate biopsy according to SNU-PCRC application

Variable Conventional group (N=432) SNU-PCRC group (N=114) p-value
Overall detection rate 176 (40.7) 74 (64.9) 0.001
High risk prostate cancer detection rate 130 (30.1) 50 (43.9) 0.036
Positive core 1.9±3.1 2.7±3.4 0.114
Gleason score     0.789
 6 44 (25.0) 22 (29.7)  
 7 (3+4) 44 (25.0) 12 (16.2)  
 7 (4+3) 33 (18.8) 14 (18.9)  
 8 31 (17.6) 16 (21.6)  
 9 19 (10.8) 8 (10.8)  
 10 3 (1.7) 0 (0)  

Values are presented as number (%) or mean±standard deviation.

SNU-PCRC: Seoul National University Prostate Cancer Risk Calculator.

Fig. 1.

Overall prostate cancer detection rate and high- risk prostate cancer detection rate according to prostate-specific antigen (PSA) interval. SNU-PCRC: Seoul National University Prostate Cancer Risk Calculator.

Table 3.

Result of applying SNU-PCRC to convention group

Variable SNU-PCRC <30% SNU-PCRC ≥30% p-value
Number 296 136  
Overall detection rate 77 (26.0) 99 (72.8) <0.001
High risk prostate cancer detection rate 46 (15.5) 84 (61.8) <0.001
Gleason score     <0.001
 6 31 (40.3) 14 (14.1)  
 7 (3+4) 24 (31.2) 18 (18.2)  
 7 (4+3) 15 (19.5) 20 (20.2)  
 8 4 (5.2) 27 (27.3)  
 9 2 (2.6) 17 (17.2)  
 10 1 (1.3) 2 (2.0)  

Values are presented as number (%).

SNU-PCRC: Seoul National University Prostate Cancer Risk Calculator.