The Korean Journal of Urological Oncology 2004;2(2):66-71.
Published online June 30, 2004.
방광암 조직에서 Insulin-like Growth Factors (IGFs)와 Insulin-like Growth Factor Binding Proteins(IGFBPs)의 발현
이민우, 강명재1, 황평한2, 정영범, 김형진
전북대학교 의과대학 비뇨기과학교실, 1병리학교실, 2소아과학교실, 의과학연구소
Expression of the Insulin-like Growth Factors(IGFs) and Insulin-like Growth Factor Binding Proteins(IGFBPs) in Bladder Cancer Tissue
Min Woo Lee , Myoung Jae Kang 1, Pyoung Han Hwang 2, Young Beom Jeong , Hyung Jin Kim
0Departments of Urology, Pathology, Jeonju, Korea
1Departments of Urology, Pediatrics and Institute for Medical Science, Chonbuk National University Medical School, Jeonju, Korea
Correspondence:  Young Beom Jeong
To demonstrate the hypothesis that tissue insulin-like growth factor(IGF)-I, -II or IGF binding protein (IGFBP)-2, -3 levels would differ between bladder cancer tissue and adjacent normal bladder and whether these factors could affect the pathologic characteristics such as tumor stage, grade in patients with bladder cancer. Materials and Methods: The study group consisted of 22 patients who underwent transurethral resection of bladder tumor. Bladder cancer specimens and adjacent normal bladder tissues were obtained. Histopathologic examinations were made by one pathologist for each specimen. All of cancer specimens were transitional cell carcinoma. There are 10 Ta low grade, 3 T1 low grade, 5 T1 high grade, 4 T2 or more high grade. The tissue expressions of IGF-I, -II or IGFBP-2, -3 in cancer and normal tissues were measured using reverse transcriptase-polymerase chain reaction(RT-PCR), respectively. Results: No significant difference was found in the expression of IGF-I and IGFBP-2 between bladder cancer and normal bladder tissues. The significant expression of IGF-II and IGFBP-3 were detected in the cancer specimens compared with the normal bladder tissues. Overexpression of the IGF-II, in particular, was observed in the tumor tissues and strongly associated with pathologic stage T1 or more rather than Ta, high grade compared with low grade tumor. Conclusions: To our knowledge, this is the first report comparing bladder cancer with normal bladder tissue for IGFs and IGFBPs expression. Our data suggest that IGF-II may have an important role in the biology of bladder cancer development and differentiation. Interestingly, increased local IGFBP-3 expression revealed in bladder cancer compared with adjacent normal tissue. We think further studies are needed to understand this phenomenon. (Korean J Uro-Oncol 2004;2:66-71)
Key Words: IGF, IGFBP, Bladder cancer
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