Histopathological Evaluation of Non-Neoplastic Renal Parenchyma Adjacent to Tumors in Partial Nephrectomy Specimens of Renal Cell Carcinoma

, Sang Hyup Lee; , Tae-Hyoung Kim; , Soon Chul Myung; , Young Tae Moon; , Kyung Do Kim; , Jung Hoon Kim

Original Article

The Korean Journal of Urological Oncology 2013;11(1):33-40.
Published online April 30, 2013.

Histopathological Evaluation of Non-Neoplastic Renal Parenchyma Adjacent to Tumors in Partial Nephrectomy Specimens of Renal Cell Carcinoma

Sang Hyup Lee , Tae-Hyoung Kim , Soon Chul Myung , Young Tae Moon , Kyung Do Kim , Jung Hoon Kim

Department of Urology, Chung-Ang University College of Medicine, Seoul, Korea

Correspondence: Jung Hoon Kim

Abstract

t to tumors using H&E staining and tubular viability was assessed by Klotho stain. Each renal unit was assigned a RENAL nephrometry score using preoperative imaging. We also investigated the correlation between RENAL score, estimated glomerular filtration rate (GFR) and glomerular and tubular viability. Results: The percentage of non-viable glomeruli was higher in the region within 2-mm from the tumor compared with the region＞2-mm from the tumor. The mean non-viable tubular distance from the tumor was 1.36±0.597mm. Only the correlation between glomerular non-viability (%) within 2-mm from the tumor and non-viable tubular distance (mm) was significant. Correlations between RENAL score and glomerular non-viability in the region ≤2- mm from the tumor and non-viable tubular distance were not significant for all RENAL factors. But, glomerular non-viability 5-10-mm from the tumor was inversely correlated with preoperative estimated GFR. Conclusions: Regardless of RENAL nephrometry scores, the viability of glomeruli and tubules within 2-mm from RCC was affected by tumor mass, and that ＞5-mm from the tumor was affected by subclinical comorbidities. These may suggest new guidelines of RCC management intraoperatively and postoperatively. (Korean J Urol Oncol 2013;11:33-40)

Key Words: Renal cell carcinoma, Renal parenchyma, Nephrectomy