The Korean Journal of Urological Oncology 2011;9(2):82-87.
Published online August 30, 2011.
성인 고환 생식세포종양에 대한 치료 및 장기 추적결과
박서용, 임수현, 이건석, 서성일, 전성수, 이현무, 최한용, 정병창
성균관대학교 의과대학 비뇨기과학교실
Management and Long-term Outcome of Testicular Germ Cell Tumor
Seo Young Park , Soo Hyun Lim , Geonseok Lee , Seongil Seo , Seongsoo Jeon , Hyun Moo Lee , Han Yong Choi , Byong Chang Jeong
Department of Urology, Sungkyunkwan University School of Medicine, Seoul, Korea
Correspondence:  Byong Chang Jeong
To present the therapeutic strategies and long-term follow-up results of testicular germ cell tumors (GCT) based on an 11-year single center experience. Materials and Methods: The medical records of testis cancer cases diagnosed between January 1996 and November 2006 were reviewed. Patient demographics, cancer histopathology and stage, adjuvant therapy, survival data are reviewed and analyzed. Results: A total of 51 testicular GCT, including seminoma in 31, and non-seminomatous GCT (NSGCT) in 20 were enrolled in the present study. Mean patient age at diagnosis was 35.6 years (range 18-69), with a median follow-up of 53 months (range 5-163). There were no cases with bilateral testicular GCT in this study cohort. Among 51patients, 30 (58.8%) were stage I, 10 (19.6%) were stage IIA/IIB, and 11 (21.6%) were IIC/III. Of the 30 patients with stage I testicular GCT, two patients who had been under surveillance showed relapse at retroperitoneal lymph nodes, and both patients cured with salvage chemotherapy. Meanwhile, there was no recurrence in 14 patients who received adjuvant chemo or radiotherapy after radical orchiectomy. The overall 5-year cancer specific survival was 95.9%. Conclusions: Our long-term follow-up results confirm the excellent prognosis for patients with testicular GCT, and indicate that surveillance does not compromise survival. In stage I testicular germ cell tumor, active surveillance could minimize treatment-related morbidity. Before deciding surveillance, however, psychological impacts on patients, economic and social costs in addition to patients' compliance should also be considered. (Korean J Urol Oncol 2011;9:82-87)
Key Words: Testicular neoplasm, Neoplasm staging, Survival
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