Analysis of Survival and Prognostic Factors of Renal Cell Carcinoma with Bone Metastasis

, Taek Sang Kim; , Su Hwan Kang; , Jung Hyun Oh; , Hyun Yul Rhew

Original Article

The Korean Journal of Urological Oncology 2010;8(3):133-137.
Published online December 1, 2010.

골전이된 신세포암 환자에서 생존과 예후인자 분석

김택상, 강수환, 오정현, 류현열

고신대학교 의과대학 비뇨기과학교실

Analysis of Survival and Prognostic Factors of Renal Cell Carcinoma with Bone Metastasis

Taek Sang Kim , Su Hwan Kang , Jung Hyun Oh , Hyun Yul Rhew

Department of Urology, Kosin University College of Medicine, Busan, Korea

Correspondence: Taek Sang Kim

Abstract

Purpose
For appropriate treatment strategies in renal cell carcinoma (RCC) with bone metastasis, information about survival and prognosis of these patients were required. However, the reports about prognosis of RCC patients with bone metastasis are rare in the literature. We reviewed the records of RCC patients with bone metastasis, analysed about survival and prognostic factors. Materials and Methods: From January 2000 to December 2009, 73 patients presented with metastasis to bone secondary to RCC. We retrospectively reviewed their medical, radiologic, and nuclear medical records. As prognostic factor, we analysed age, sex, pathologic type and stage of primary RCC, metastasis to other organ, the interval between the diagnosis of RCC and bone metastasis, and orthopedic treatment of bone metastasis. The relationship between survival and each factors were analysed and we categorized all patient into two different groups for analyse the difference in survival duration. Results: The median survival time from bone metastasis was 12 month, 34 survival rate at 1, 2 and 5 year were 39.7%, 23.3%, and 2.7%. In the multivariate analysis, prognostic factors correlated with longer survival were the absence of metastasis to other organ and orthopedic surgery of bony lesion. Conclusions: As prognostic factors predicting survival, the absence of metastasis to other organ and orthopedic surgery of bony lesion were identified. These would offer the useful tools for predicting survival and prognosis, and making the treatment plan. (Korean J Urol Oncol 2010;8:133-137)

Key Words: Renal cell carcinoma, Metastasis, Prognosis