The Korean Journal of Urological Oncology 2010;8(1):40-46.
Published online April 1, 2010.
전립선암으로 근치적 전립선적출술을 받은 한국인의 특징과 예후
김대성, 변석수, 이상은, 이은식, 최한용1, 정병하2, 최영득2, 안한종3, 황태곤4, 이강현5, 김원재6, 정문기7, 천준8, 김형진9, 정태영10, 권태균11
서울대학교 의과대학 비뇨기과학교실, 1성균관대학교 의과대학 비뇨기과학교실, 2연세대학교 의과대학 비교기과학교실, 3울산대학교 의과대학 비뇨기과학교실, 4가톨릭대학교 의과대학 비뇨기과학교실, 5국립암센터 비뇨기과, 6충북대학교 의과대학 비뇨기과학교실, 7부산대학교 의학전문대학원 비뇨기과학교실, 8고려대학교 의과대학 비뇨기과학교실, 9전북대학교 의과대학 비뇨기과학교실, 10서울보훈병원 비뇨기과, 11경북대학교 의과대학 비뇨기과학교실
The Features and Prognosis of Korean Who Underwent Radical Prostatectomy in Prostate Cance
Dae Sung Kim , Seok-Soo Byun , Sang Eun Lee , Eunsik Lee , Han Yong Choi 1, Byung Ha Chung 2, Young Deuk Choi 2, Hanjong Ahn 3, Tae-Kon Hwang 4, Kang Hyun Lee 5, Wun-Jae Kim 6, Moon Kee Chung 7, Jun Cheon 8, Hyung Jin Kim 9, Tae Young Jung 10, Tae Gyun Kwon 11
0Department of Urology, College of Medicine, Seoul National University, Korea
1Department of Urology, Sungkyunkwan University, Korea
2Department of Urology, Yonsei University, Seoul, Korea
3Department of Urology, University of Ulsan, Ulsan, Korea
4Department of Urology, The Catholic University of Korea, Korea
5Department of Urology, National Cancer Center, Seoul, Korea
6Department of Urology, Chungbuk National University, Cheongju, Korea
7Department of Urology, Pusan National University, Busan, Korea
8Department of Urology, Korea University, Seoul, Korea
9Department of Urology, Chonbuk National University, Jeonju, Korea
10Department of Urology, Seoul Veterans Hospital, Seoul, Korea
11Department of Urology, Kyungpook National University, Deagu, Korea
Correspondence:  Dae Sung Kim
Abstract
Purpose
There is a great difference between the prostate cancer in Asian men compared to Western men. We evaluated the clinicopathologic features and prognosis of Korean men with prostate cancer who underwent radical prostatectomy. Materials and Methods: We reviewed retrospectively the clinicopathologic parameters including age, preoperative PSA, stage, Gleason score and so on in 2,783 men underwent radical prostatectomy in 14 institutions. Of 2,783 men, patients with prior radiotherapy, neoadjuvant treatment, suspicious lymph node invasion, distant metastasis and treatment failure were excluded. We evaluated recent change in clinical parameters. 2,081 men with localized prostate cancer were analyzed for the biochemical recurrence-free survival rates. Results: Proportion of patients with serum PSA of less than 10ng/ml were 38.9% in 1999. However the proportion were 68.6% in 2008. The 5-year overall biochemical recurrence-free survival rate (BCR-FS) was 48%. The 5-year BCR-FS according to the preoperative serum PSA, biopsy Gleason score, pathologic T stage, margin positivity had the lower level than Western series. Conclusions: The proportion of patients with serum PSA <10ng/ml were increased in Korean men with prostate cancer. However, the BCR-FS had the lower level than Western men. Therefore, we must consider that the prostate cancer in Korean men have a unfavorable prognosis compared with Western men. (Korean J Urol Oncol 2010;8:40-46)
Key Words: Prostate cancer, Recurrence, Prostatectomy


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