The Korean Journal of Urological Oncology 2007;5(1):42-47.
Published online April 1, 2007.
한국 남성에서 전립선특이항원밀도에 따른 12부위 확장생검법 및 6부위 생검법의 전립선암 진단율 비교
김태범, 박찬수, 송상훈, 구자현1, 정 현1, 곽 철
서울대학교 의과대학 비뇨기과학교실, 1서울시립보라매병원 비뇨기과
The Comparison of Prostate Cancer Detection Rate of 12 Core Biopsy and 6 Core Biopsy according to Prostate-specific Antigen Density in Korean Men
Tae Beom Kim , Chan Soo Park , Sang Hoon Song , Ja Hyun Ku 1, Hyeon Jeong 1, Chul Kwak
0Department of Urology, Seoul National University College of Medicine, Korea
1Department of Urology, Seoul Municipal Boramae Hospital, Seoul, Korea
Correspondence:  Chul Kwak
Abstract
Purpose
The purpose of our study was to evaluate the effectiveness of the 12 core biopsy protocol in detecting prostate cancer by comparing it with the 6 core biopsy protocol according to prostate-specific antigen density (PSAD). Materials and Methods: Between January 2000 and April 2005, transrectal ultrasound-guided prostate biopsies were performed on 1,158 men suspected of prostate cancer. The cancer detection rate of the two methods was analyzed according to PSAD. Results: The cancer detection rate was 29.6%(58/196) and 28.3%(272/962) for the 6 core biopsy protocol and the 12 core biopsy protocol, respectively. All patients were stratified into 2 groups according to PSAD level; the PSAD<0.2 group(n=748) and the PSAD≥0.2 group(n=410). The detection rate of the 12 core biopsy protocol was higher than that of the 6 core biopsy protocol in the PSAD<0.2 group(p=0.025). Then, all patients were stratified into 4 groups according to PSAD level; group A: PSAD<0.1(n=251), group B: 0.1≤PSAD<0.2 (n=497), group C: 0.2≤PSAD<0.3(n=199) and group D: PSAD≥0.3(n=211). In the group B, the detection rate of the 12 core biopsy protocol was higher than that of the 6 core biopsy protocol(p=0.018). Conclusions: These results show that the cancer detection rate of the 12 core biopsy protocol is higher than that of the 6 core biopsy protocol in patients with 0.1≤PSAD<0.2 and suggest that PSAD may be a useful factor for determining the number of cores in prostate biopsy. (Korean J Urol Oncol 2007;5:42-47)
Key Words: Prostate cancer, Prostate-specific antigen, Biopsy


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